Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2212531생성일: 2026년 10월 27일
1,4-Dibromobutane → 5-(4-Bromo-butoxy)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester
https://huagongshe.com/reaction/2212531
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,4-Dibromobutane | HCID 8056 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | N-Boc-5-Hydroxyindoline | HCID 10657398 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 5-(4-Bromo-butoxy)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester | HCID 69514776 | 475.3% |
반응 단계
9.41 g (40 mmol) 5-Hydroxy-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester in 90 ml acetone were treated with 16.6 g (6 mmol) K2CO3 (powdered) and 17.3 g (5 mmol) 1,4-dibromobutane. The suspension was stirred at 50° C. for 4 h, cooled to RT, filtered and concentrated. Column chromatography on silica gel with CH2Cl2 yielded 8.8 g (60%) 5-(4-Bromo-butoxy)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester as colorless solid, MS: 370 (MH+, 1Br).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07102007B2 |
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| 출처 데이터셋 | uspto-grants-2006_09 |
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| ORD ID | ord-bebbd0d6b2eb4e3d89c699a38d1fab2f |
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| 출처 메모 | uspto-grants-2006_09 |
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