Trifluoroacetic acid → HCID 10003860, compound

Participants

Reaction Steps

4-{3-Hydroxy-2-hydroxycarbamoyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-propyl}-piperidine-1-carboxylic acid tert-butyl ester (0.05 g, 0.075 mmol) from Example 17 was taken up in methylene chloride (3 mL) and TFA (2 mL) under nitrogen atmosphere at room temperature. The reaction was complete after 2 h, was concentrated, taken up in water (5 mL), and freeze-dried to give the title compound (0.045 g, 88%) as a white solid. MS found: (M+H)+=450.

Provenance & Evidence