Trifluoroacetic acid → HCID 10049438, compound

Participants

Reaction Steps

4-{3-Hydroxy-2-hydroxycarbamoyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-propyl}-piperazine-1-carboxylic acid tert-butyl ester (0.077 g, 0.099 mmol) from Example 19 was taken up in methylene chloride (3 mL) and TFA (2 mL) under nitrogen atmosphere at room temperature. The reaction was complete after 2 h, was concentrated, taken up in water (5 mL), and freeze-dried to give the title compound (0.069 g, 88%) as a white solid. MS found: (M+H)+=451.

Provenance & Evidence