Trifluoroacetic acid → HCID 21966708, compound

Participants

Reaction Steps

Benzyl-{3-hydroxy-2-hydroxycarbamoyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-propyl}-carbamic acid tert-butyl ester (0.07 g, 0.10 mmol) from Example 21 was taken up in methylene chloride (3 mL) and TFA (2 mL) under nitrogen atmosphere at room temperature. The reaction was complete after 2 h, was concentrated, taken up in water (5 mL), and freeze-dried to give the title compound (0.073 g, 100%) as a white solid. MS found: (M+H)+=472.

Provenance & Evidence