HCID 21966470, compound → HCID 21966445, compound

Participants

Reaction Steps

To a solution of N-(3-methoxy-4-methyl-phenyl)-isobutyramide (5.0 g, 24.1 mmol) in dichloromethane (200 mL) was added tetrabutylammonium tribromide (12.2 g, 25.3 mmol) at 0° C. The mixture was then stirred at room temperature for 20 hours. The solution was washed with water, brine, aqueous sodium bicarbonate solution, brine, dried over MgSO4, filtered and evaporated under reduced pressure to give 6.83 g of N-(2-bromo-5-methoxy-4-methyl-phenyl)-isobutyramide (99%). 1H NMR (300 MHz, CDCl3, ppm): δ: 1.29 (d, J=7.03 Hz, 6 H), 2.15 (s, 3 H), 2.59 (m, 1 H), 3.84 (s, 1 H), 7.24 (s, 1 H), 7.65 (bs, 1 H), 8.08 (s, 1 H).

Provenance & Evidence