Oxygen → 11-Ethyl-8-(2-hydroxyethyl)-5-methyl-5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Participants

Reaction Steps

A stream of ozonized oxygen was bubbled through a cold (−78° C.) solution of 5,11-dihydro-11-ethyl-5-methyl-8-(2-propenyl)-6H-dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one 1g (22.19 g, 75.4 mmol) in CH2Cl2 (150 mL) and MeOH (150 mL) for 2.5 h. A stream of N2 was next bubbled through the solution for 15 min and then solid NaBH4 (4.99 g, 132 mmol) was added to the solution. The reaction mixture was allowed to warm to room temperature. After 1 h, aqueous saturated NH4Cl (200 mL) was added and the mixture was stirred at room temperature for 2 h. The organic solvents were removed under reduced pressure. Water (300 mL) and CHCl3 (300 mL) were added to the residue. The phases were separated and the aqueous layer was extracted with CHCl3 (3×300 mL). The combined organic layers were dried (MgSO4), filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (EtOAc/CHCl3, 4/1) to give compound 1 h (16.1 g, 72% yield) as a white solid.

Provenance & Evidence