HCID 69658837, compound → HCID 21955926, compound

Participants

Reaction Steps

A solution of 3-(2-oxo-cyclopentylidenemethyl)-1H-indole-5-carbonitrile (800 mg, 3.39 mMol) in methanol (120 mL) was hydrogentated at atmospheric pressure for 16 h over 10% Pd/C catalyst (300 mg). The mixture was filtered and the filtrate was concentrated in vacuo. The residue was purified by silica gel chromatography (5% ethyl acetate/hexanes-80% ethyl acetate/hexanes) to give 3-(2-oxo-cyclopentylmethyl)-1H-indole-5-carbonitrile (140 mg, 18%). LCMS (4.6×50 mm XTERRA C-18 S5 column, 5 mL/min, 0–100% MeOH/H2O/0.1% TFA, 2 min gradient): Tr=1.51 min, m/e 261 (M+H+Na)+.

Provenance & Evidence