Tert-butyl 4-(3-ethoxy-3-oxoprop-1-YN-1-YL)-4-hydroxypiperidine-1-carboxylate → tert-Butyl 4-(3-ethoxy-3-oxopropyl)-4-hydroxypiperidine-1-carboxylate

Participants

Reaction Steps

Palladium on carbon (5%, 1 g) in water (10 mL) was added to a solution of 1,1-dimethylethyl 4-(3-ethoxy-3-oxo-1-propynyl)-4-hydroxy-1-piperidinecarboxylate (Description 76, 14.6 g, 0.046 mol) in ethanol (200 mL) and the mixture was shaken under hydrogen (45 psi) for 90 minutes. The mixture was filtered through a glass fibre pad and the solvent was evaporated under reduced pressure to give the title compound. m/z (ES+) 302 (M+1).

Provenance & Evidence