(RS)-alpha-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetic acid → (RS)-N-(4-Oxo-1-phenylcyclohexyl)-alpha-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetamide

Participants

Reaction Steps

Prepared from (RS)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetic acid (Description 35) and 4-oxo-1-phenylcyclohexylamine hydrochloride (Description 18) according to the method of Example 1. 1H NMR (400 MHz, CDCl3) δ 7.80 (1H, s), 7.73 (2H, s), 7.35–7.2 (5H, m), 5.80 (1H, br s), 5.75–5.63 (1H, m), 5.13–5.05 (2H, m), 3.56 (1H, dd, J 7, 6 Hz), 2.90–2.80 (2H, m), 2.65–2.55 (1H, m), and 2.52–2.30 (7H, m).

Provenance & Evidence