2-(3,5-Bis(trifluoromethyl)phenyl)propanoic acid → (RS)-alpha-Methyl-N-[1-(2-Fluorophenyl)-4-oxocyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide

Participants

Reaction Steps

Prepared from (RS)-α-methyl-3,5-bis(trifluoromethyl)benzeneacetic acid (Description 4) and 1-(2-fluorophenyl)-4-oxocyclohexylamine hydrochloride (Description 180) according to the method of Example 1. 1H NMR (360 MHz, CDCl3) δ 7.79 (1H, s), 7.68 (2H, s), 7.40–7.35 (1H, m), 7.27–7.21 (1H, m), 7.14–7.10 (1H, m), 6.93–6.86 (1H, m), 5.95 (1H, s), 3.71 (1H, q J 7.0 Hz), 3.08–3.00 (1H, m), 2.86–2.78 (1H, m), 2.56–2.20 (6H, m), and 1.49 (3H, d, J 7.0 Hz).

Provenance & Evidence