Hydrazine hydrate (1:1) → 3-amino-5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyridine

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Reaction Steps

Hydrazine hydrate (0.52 ml, 10.7 mmol) was added to a stirred solution of 5-chloro-2-(2,3-difluorophenyl)isonicotinonitrile (1.22 g, 4.9 mmol) in pyridine (12.5 mL). The reaction mixture was stirred at reflux for 2 hours, allowed to cool and concentrated. Purification by column chromatography using a gradient of 5–10% methanol in dichloromethane as eluent afforded the title compound as a solid.

Provenance & Evidence