反应详情

A suspension of Pd/C (0.25 g of 10%) in MeOH (5 mL) was mixed with a solution of 2-(2-methoxy-4-nitrophenyl)pyridine (0.5 g, 2.17 mmol) in MeOH (5 mL). The resulting reaction mixture was stirred vigorously for 12 h under an atmosphere of hydrogen, filtered through a pad of celite, and the filtrate was concentrated and purified by flash column chromatography on silica gel with EtOAc:hexanes (1:9 to 3:2) to afford 3-methoxy-4-pyridin-2-ylaniline.

1. customThe resulting reaction mixture
2. filtrationfiltered through a pad of celite
3. concentrationthe filtrate was concentrated
4. custompurified by flash column chromatography on silica gel with EtOAc:hexanes (1:9 to 3:2)