3-Bromo-4-methoxybenzoic acid → 4-Methoxy-3-(trifluoromethyl)benzoic acid

HRID 2213130Notes

Reaction equation

Br[C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=[O:6].[F:13][C:14]([F:19])([F:18])C([O-])=O.[K+]>>[CH3:12][O:11][C:10]1[CH:9]=[CH:8][C:4]([C:5]([OH:7])=[O:6])=[CH:3][C:2]=1[C:14]([F:19])([F:18])[F:13]

Participants

Reactant 2

HCID 668363-Bromo-4-methoxybenzoic acid

HCID 23662811Potassium trifluoroacetate

Product 1

HCID 27752954-Methoxy-3-(trifluoromethyl)benzoic acid

Procedure

The title compound was prepared from 3-bromo-4-methoxybenzoic acid and potassium trifluoroacetate in a manner similar to that of Preparation 6.

Workup

customof Preparation 6

Sources & evidence

ORD record: ord-cf1d3ef8f4f54d79a253b7d05be2bbab
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07105536B2

Reaction notes

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