反应详情

温度

50 °C

A mixture of tert-butyl cyanomethylcarbamate (1.61 g; 10 mmol), 2,3-diaminopyridine (0.56 g; 5 mmol), N-acetylcysteine (1.68 g; 10 mmol) in 10 ml of CH3OH was heated at 50° C. for 89 h. It was then concentrated, and the residue was taken up in a little CH3OH and filtered through an acidic ion exchanger (acetate on polymeric support). Renewed concentration and chromatography on silica gel (CH2Cl2/CH3OH 5%) afforded 1.09 g of the required product;

1. concentrationIt was then concentrated
2. filtrationfiltered through an acidic ion exchanger (acetate on polymeric support)
3. concentrationRenewed concentration and chromatography on silica gel (CH2Cl2/CH3OH 5%)