HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5-{2-[(3-{[(Benzylamino)carbonyl]amino}benzyl)amino]-2-oxoethyl}-6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-[3-(Aminomethyl)phenyl]-N'-benzylurea | HCID 21955411 | — |
| Reactant | 11-(2-tert-butoxy-2-oxoethyl)-6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-5-ylacetate | HCID 21955461 | — |
| Solvent | MTBE methanol | HCID 22277986 | — |
| Product | 5-{2-[(3-{[(Benzylamino)carbonyl]amino}benzyl)amino]-2-oxoethyl}-6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl acetate | HCID 21955513 | — |
Reaction Steps
Coupling of 11-(2-tert-butoxy-2-oxoethyl)-6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-5-yl acetate (66) with (3-{[(benzylamino)-carbonyl]amino}phenyl)methanamine (hydrochloride) (41), TFA cleavage and stirring of the resulting crude product with methyl tert-butyl ether/CH3OH 19:1 afforded 0.61 g of slightly brownish solids; ESI-MS [M+H+]=563.25.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07105508B1 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-1bce2b55572f4327be5a30c3f8323560 |
| Source note | uspto-grants-2006_09 |