4-Hydrazino-N-methylbenzenemethanesulfonamide hydrochloride → HCID 178486288, compound

HRID 2213258Notes

Reaction equation

HRID 2213258 reaction equation
[OH:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](=O)[C:7](=[O:11])[NH:8]2)=[C:4](NC(=O)C)[CH:3]=1.Cl.[NH:18]([C:20]1[CH:31]=[CH:30][C:23]([CH2:24][S:25]([NH:28][CH3:29])(=[O:27])=[O:26])=[CH:22][CH:21]=1)[NH2:19]>>[OH:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](=[N:19][NH:18][C:20]3[CH:31]=[CH:30][C:23]([CH2:24][S:25](=[O:27])(=[O:26])[NH:28][CH3:29])=[CH:22][CH:21]=3)[C:7](=[O:11])[NH:8]2)=[CH:4][C:3]=1[NH:8][C:7](=[O:11])[CH3:6]

Participants

3

Reactant 2

HCID 142342634-Hydrazino-N-methylbenzenemethanesulfonamide hydrochlorideHCID 21956268N-(6-hydroxy-2,3-dioxo-2,3-dihydro-1H-indol-4-yl)acetamide

Product 1

HCID 178486288HCID 178486288, compoundYield 4%

Procedure

Condensation of N-(6-hydroxy-2,3-dioxo-2,3-dihydro-1H-indol-4-yl)acetamide and 4-hydrazino-N-methyl-benzylsulfonamide hydrochloride according to Procedure G gave the title compound in 4% yield: 1H NMR (DMSO-d6): δ 2.04 (s, 3H), 2.51 (d, J=4.8 Hz, 3H), 4.24 (s, 2H), 6.45 (s, 1H), 6.84 (t, J=4.8 Hz, 1H), 7.30 (s, 4H), 7.82 (s, 1H), 9.12 (s, 1H), 10.20 (s, 1H), 10.77 (s, 1H), 12.50 (s, 1H); APCI-MS m/z 416 (M−H)−.

Sources & evidence

ORD record
ord-46f03ac306fd4b708572b94b1e035367
Source dataset
uspto-grants-2006_09
Patent number
US07105529B2

Reaction notes

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