Methanol, 1,1-diethoxy-, 1-acetate → 3-[Ethoxymethylidene]-5-phenyl-1H-pyrrolo[2,3-b]pyridin-2-one

HRID 2213316Notes

Reaction equation

HRID 2213316 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]3[CH2:15][C:14](=[O:16])[NH:13][C:10]3=[N:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:17]([O:20][CH:21](OCC)OCC)(=O)[CH3:18]>>[CH2:17]([O:20][CH:21]=[C:15]1[C:9]2[C:10](=[N:11][CH:12]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:8]=2)[NH:13][C:14]1=[O:16])[CH3:18]

Participants

3

Reactant 2

HCID 84166Methanol, 1,1-diethoxy-, 1-acetateHCID 155040635-phenyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

Product 1

HCID 543090473-[Ethoxymethylidene]-5-phenyl-1H-pyrrolo[2,3-b]pyridin-2-one

Procedure

This compound was synthesized from 5-phenyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one and diethoxymethyl acetate according to Procedure A. 1H NMR 400 MHz (DMSO-d6): δ 10.93 (s, 1H); 8.24 (s, 1H); 7.86–7.82 (m, 2H); 7.62–7.56 (m, 2H); 7.44 (m, 2H); 7.34 (m, 1H); 4.40 (m, 2H); 1.35 (m, 3H).

Sources & evidence

ORD record
ord-15acf3b14ab941f18d25e1030dec4f6d
Source dataset
uspto-grants-2006_09
Patent number
US07105529B2

Reaction notes

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