Hydrochloric Acid → HCID 10279035, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of example 34 (800 mg, 1.5 mmol) in THF/Ethanol (5/20 mL) was added 1N NaOH (10 mmol, 10 mL). The resulting mixture was stirred at 50° C. for 2 hours, and after cooling at room temperature 1N HCl (10 mmol, 10 mL) was added. The resulting mixture was concentrated in vacuo, then the residue was flash chromatographed CH2Cl2/MeOH (98:2) to give the title compound (310 mg, 0.61 mmol) in a 40% yield as a colorless oil.

Provenance & Evidence