Dimethylformamide → 4-Fluorophenylacetyl chloride

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-fluorophenylacetic acid (12.2 g, 79 mmol.) in dry DCM (200 ml) at 0° C. was added oxalyl chloride (7.8 ml, 89 mmol.) and DMF (0.3 ml) and the resulting effervescing mixture stirred at 0° C. for 30 minutes then at ambient temperature for a further 45 minutes. The effervescence had ceased after this time and the solvent was evaporated. To the residue was added toluene (50 ml) and the solvent evaporated. The addition of toluene and evaporation was repeated to leave a residue of 4-fluorophenylacetyl chloride.

Provenance & Evidence