HCID 7216755, compound → HCID 86591937, compound

HRID 2213345Notes

Reaction equation

[NH2:1][CH:2]1[C:8](=[O:9])[N:7]([CH:10]([CH3:12])[CH3:11])[C:6]2[CH:13]=[CH:14][CH:15]=[CH:16][C:5]=2[C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[F:23])=[N:3]1.N[C@@H]1C(=O)N(C)C2C=CC=CC=2C(C2C=CC=CC=2)=N1.[Cl:44][C:45]1[CH:46]=[C:47]([CH:56]=[CH:57][C:58]=1[Cl:59])[CH2:48][C@H:49]([CH2:53][CH:54]=[CH2:55])[C:50](O)=[O:51]>>[F:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[C:4]1[C:5]2[CH:16]=[CH:15][CH:14]=[CH:13][C:6]=2[N:7]([CH:10]([CH3:12])[CH3:11])[C:8](=[O:9])[CH:2]([NH:1][C:50](=[O:51])[C@H:49]([CH2:48][C:47]2[CH:56]=[CH:57][C:58]([Cl:59])=[C:45]([Cl:44])[CH:46]=2)[CH2:53][CH:54]=[CH2:55])[N:3]=1

Participants

Reactant 3

HCID 7216755HCID 7216755, compound

HCID 21955579HCID 21955579, compound

HCID 69633109HCID 69633109, compound

Product 1

HCID 86591937HCID 86591937, compound

Procedure

Prepared from 3-amino-5-(2-fluoro-phenyl)-1-isopropyl-2-oxo-1,3-dihydro-2H-benzo[e][1,4]diazepine [available in an analogous fashion to (S)-3amino-1-methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one (i.e. J. Org. Chem. 1987, 52, 3232)] and (2S)-2-(3,4dichlorobenzyl)-pent-4-enoic acid using the procedure of Step 1E shown in Scheme 1.

Sources & evidence

ORD record: ord-4502dd9cf69940af89bfaca028831884
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07105509B2

Reaction notes

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