HCID 21930930, compound → HCID 86591938, compound

HRID 2213346Notes

Reaction equation

HRID 2213346 reaction equation
[NH2:1][CH:2]1[C:8](=[O:9])[N:7]([CH2:10][C:11]([F:14])([F:13])[F:12])[C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]=2[C:4]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[F:25])=[N:3]1.N1C(=O)C=NC=CC=1.[Cl:34][C:35]1[CH:36]=[C:37]([CH:46]=[CH:47][C:48]=1[Cl:49])[CH2:38][C@H:39]([CH2:43][CH:44]=[CH2:45])[C:40](O)=[O:41]>>[F:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[C:4]1[C:5]2[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=2[N:7]([CH2:10][C:11]([F:14])([F:12])[F:13])[C:8](=[O:9])[C@@H:2]([NH:1][C:40](=[O:41])[CH:39]([CH2:38][C:37]2[CH:46]=[CH:47][C:48]([Cl:49])=[C:35]([Cl:34])[CH:36]=2)[CH2:43][CH:44]=[CH2:45])[N:3]=1

Participants

4

Reactant 3

HCID 21930930HCID 21930930, compoundHCID 21955728HCID 21955728, compoundHCID 69633109HCID 69633109, compound

Product 1

HCID 86591938HCID 86591938, compound

Procedure

Prepared from 3-amino-5-(2-fluoro-phenyl)-1-(2,2,2-trifluoroethyl)-2-oxo-1,3-dihydro-2H-benzo[e][1,4]diazepine [available in an analogous fashion to (S)-3-amino-1-methyl-5-phenyl-1,3dihydro-2H-benzole][1,4]diazepin-2-one (i.e. J. Org. Chem. 1987, 52, 3232)] and (2S)-2-(3,4-dichlorobenzyl)-pent-4-enoic acid using the procedure of Step 1E shown in Scheme 1.

Sources & evidence

ORD record
ord-707db4e179b44b3483e3277755f80ec4
Source dataset
uspto-grants-2006_09
Patent number
US07105509B2

Reaction notes

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