HCID 21955666, compound → HCID 69632622, compound

Participants

Reaction Steps

4-(3,4-Difluorophenyl)-3-methyl-2(5H)-furanone (235 mg, 1.1 mmol.) was dissolved in methanol (20 ml) in a thick-walled flask and degassed by nitrogen bubbling. Palladium on charcoal (10%, 300 mg) was added and the flask shaken under an atmosphere of hydrogen at 40 psi on a Parr hydrogenator for 72 hours. The reaction was placed under nitrogen and filtered through a pad of Celite® washing well with methanol and the combined washings evaporated to afford the desired cis-dihydro-4-(3,4-difluorophenyl)-3-methyl-2(3H)-furanone as an oil (230 mg).

Provenance & Evidence