Ethyl difluoroacetate → HCID 10340972, compound

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Reaction Steps

The compound is prepared from {3-[3,5-difluoro-4-(4-oxo-3,4-dihydro-2H-pyridin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-carbamic acid tert-butyl ester (402 mg, 0.92 mmol) and ethyl difluoroacetate (360 mg, 2.88 mmol) following the method described in example 9. The crude product is purified by silica gel column chromatography (eluent: EtOAc) to give a white solid. Yield 68 mg (18%). MS (m/z): 402 [M+1]+. 1H NMR (300 MHz, DMSO-d6): 9.16 (br. t, 1H), 7.46–7.38 (m, 3H), 6.24 (dd, J=11.0 and 14.8 Hz, 1H), 4.99 (d, J=7.4 Hz, 1H), 4.85–4.81 (m, 1H), 4.15 (t, J=9.3 Hz, 1H), 3.81–3.74 (m, 3H), 3.52 (t, J=5.5 Hz, 2H), 2.48 (m, 2H).

Provenance & Evidence