1-(4-Chlorophenyl)cyclohexanecarboxylic acid → 1-(4-chlorophenyl)-N-(3-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}propyl)cyclohexanecarboxamide

Participants

Reaction Steps

Example 45 was prepared from 1-(4-chlorophenyl)cyclohexanecarboxylic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}-2-methylpropanamide according to the procedures described in Scheme 9: 1H NMR (400 MHz, CDCl3) δ 7.57 (s, 1H), 7.52 (s, 1H), 7.38–7.35 (m, 2H), 7.30–7.21 (m, 4H), 6.93 (d, 1H, J=7.2 Hz), 6.88–6.83 (m, 1H), 3.28 (q, 2H, J=5.6 Hz), 2.95–2.88 (m, 2H), 2.56–2.41 (m, 2H), 2.35–2.26 (m, 3H), 2.07 (s, 1H), 1.96–1.84 (m, 4H), 1.83–1.76 (m, 2H), 1.70–1.53 (m, 10H), 1.24 (d, 6H, J=7.1 Hz); ESMS m/e: 524.3 (M+H)+.

Provenance & Evidence