2-(4-Fluorophenyl)propionic acid → 2-(4-fluorophenyl)-N-(3-{4-[3-(propionylamino)phenyl]-1-piperidinyl}propyl)propanamide

HRID 2213435Notes

Reaction equation

HRID 2213435 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:12])[C:9]([OH:11])=O)=[CH:4][CH:3]=1.[NH2:13][CH2:14][CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][CH:20]([C:23]2[CH:24]=[C:25]([NH:29][C:30](=[O:33])[CH2:31][CH3:32])[CH:26]=[CH:27][CH:28]=2)[CH2:19][CH2:18]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH3:12])[C:9]([NH:13][CH2:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][CH:20]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([NH:29][C:30](=[O:33])[CH2:31][CH3:32])[CH:24]=3)[CH2:19][CH2:18]2)=[O:11])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27239152-(4-Fluorophenyl)propionic acidHCID 21957142N-{3-[1-(3-aminopropyl)4-piperidinyl]phenyl}propanamide

Product 1

HCID 219571362-(4-fluorophenyl)-N-(3-{4-[3-(propionylamino)phenyl]-1-piperidinyl}propyl)propanamide

Procedure

Example 64 was prepared from 2-(4-fluorophenyl)propanoic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}propanamide according to the procedures described in Scheme 10: ESMS m/e: 440.4 (M+H)+.

Sources & evidence

ORD record
ord-58a7148c8b494691ad00588600821857
Source dataset
uspto-grants-2006_09
Patent number
US07105544B2

Reaction notes

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