Triphenylacetic acid → N-[3-(1-{3-[(2,2,2-triphenylacetyl)amino]propyl}-4-piperidinyl)phenyl]cyclopropanecarboxamide

HRID 2213481Notes

Reaction equation

HRID 2213481 reaction equation
[C:1]1([C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](O)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:23][CH2:24][CH2:25][CH2:26][N:27]1[CH2:32][CH2:31][CH:30]([C:33]2[CH:34]=[C:35]([NH:39][C:40]([CH:42]3[CH2:44][CH2:43]3)=[O:41])[CH:36]=[CH:37][CH:38]=2)[CH2:29][CH2:28]1>>[C:17]1([C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:8]([NH:23][CH2:24][CH2:25][CH2:26][N:27]2[CH2:32][CH2:31][CH:30]([C:33]3[CH:34]=[C:35]([NH:39][C:40]([CH:42]4[CH2:44][CH2:43]4)=[O:41])[CH:36]=[CH:37][CH:38]=3)[CH2:29][CH2:28]2)=[O:9])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 68992Triphenylacetic acidHCID 21957166N-{3-[1-(3-aminopropyl)4-piperidinyl]phenyl}cyclopropanecarboxamide

Product 1

HCID 21957225N-[3-(1-{3-[(2,2,2-triphenylacetyl)amino]propyl}-4-piperidinyl)phenyl]cyclopropanecarboxamide

Procedure

Example 114 was prepared from triphenylacetic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}cyclopropanecarboxamide according to the procedures described in Scheme 10: ESMS m/e: 572.3 (M+H)+.

Sources & evidence

ORD record
ord-66859e91406c4e0fa428c48b27cbd7f3
Source dataset
uspto-grants-2006_09
Patent number
US07105544B2

Reaction notes

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