1-(4-Fluorophenyl)cyclopentanecarboxylic acid → HCID 21957186, compound

HRID 2213487Notes

Reaction equation

HRID 2213487 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:13]([OH:15])=O)[CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[NH2:16][CH2:17][CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][CH:23]([C:26]2[CH:27]=[C:28]([NH:32][C:33]([CH:35]3[CH2:37][CH2:36]3)=[O:34])[CH:29]=[CH:30][CH:31]=2)[CH2:22][CH2:21]1>>[CH:35]1([C:33]([NH:32][C:28]2[CH:27]=[C:26]([CH:23]3[CH2:22][CH2:21][N:20]([CH2:19][CH2:18][CH2:17][NH:16][C:13]([C:8]4([C:5]5[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=5)[CH2:9][CH2:10][CH2:11][CH2:12]4)=[O:15])[CH2:25][CH2:24]3)[CH:31]=[CH:30][CH:29]=2)=[O:34])[CH2:36][CH2:37]1

Participants

3

Reactant 2

HCID 7361331-(4-Fluorophenyl)cyclopentanecarboxylic acidHCID 21957166N-{3-[1-(3-aminopropyl)4-piperidinyl]phenyl}cyclopropanecarboxamide

Product 1

HCID 21957186HCID 21957186, compound

Procedure

Example 121 was prepared from 1-(4-fluorophenyl)cyclopentanecarboxylic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}cyclopropanecarboxamide according to the procedures described in Scheme 10: 1H NMR (400 MHz, CDCl3) δ 7.94–7.72 (br, 1H), 7.48–6.84 (m, 7H), 6.75 (d, 1H, J=7.2 Hz), 6.68–6.55 (br, 1H), 3.25–3.05 (m, 4H), 2.58–2.39 (m, 3H), 2.33–2.15 (m, 2H), 2.00–1.48 (m, 15H), 1.13–1.01 (m, 2H), 0.93–0.73 (m, 2H); ESMS m/e: 492.3 (M+H)+.

Sources & evidence

ORD record
ord-83b56dd6b39a4463b7059c411f7a1f3d
Source dataset
uspto-grants-2006_09
Patent number
US07105544B2

Reaction notes

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