1-(2-Chloro-4-fluorophenyl)cyclohexanecarboxylic acid → HCID 21957236, compound

HRID 2213513Notes

Reaction equation

HRID 2213513 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1([C:15]([OH:17])=O)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1.[NH2:18][CH2:19][CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][CH:25]([C:28]2[CH:29]=[C:30]([NH:34][C:35](=[O:40])[O:36][CH:37]([CH3:39])[CH3:38])[CH:31]=[CH:32][CH:33]=2)[CH2:24][CH2:23]1>>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1([C:15]([NH:18][CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][CH:25]([C:28]3[CH:29]=[C:30]([NH:34][C:35](=[O:40])[O:36][CH:37]([CH3:38])[CH3:39])[CH:31]=[CH:32][CH:33]=3)[CH2:24][CH2:23]2)=[O:17])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 12681661-(2-Chloro-4-fluorophenyl)cyclohexanecarboxylic acidHCID 21957208Isopropyl 3-[1-(3-aminopropyl)-4-piperidinyl]phenylcarbamate

Product 1

HCID 21957236HCID 21957236, compound

Procedure

Example 147 was prepared from 1-(2-chloro-4-fluorophenyl)cyclohexanecarboxylic acid and isopropyl 3-[1-(3-aminopropyl)-4-piperidinyl]phenylcarbamate according to the procedures described in Scheme 9: ESMS m/e: 558.1 (M+H)+.

Sources & evidence

ORD record
ord-dae27b4f9e714d5ba557034ecaeb358f
Source dataset
uspto-grants-2006_09
Patent number
US07105544B2

Reaction notes

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