Diphenylpropionic acid → N-[3-(1-{3-[(3,3-diphenylpropanoyl)amino]propyl}-4-piperidinyl)phenyl]cyclopropanecarboxamide

HRID 2213517Notes

Reaction equation

HRID 2213517 reaction equation
[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][C:9]([OH:11])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:18][CH2:19][CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][CH:25]([C:28]2[CH:29]=[C:30]([NH:34][C:35]([CH:37]3[CH2:39][CH2:38]3)=[O:36])[CH:31]=[CH:32][CH:33]=2)[CH2:24][CH2:23]1>>[C:12]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:8][C:9]([NH:18][CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][CH:25]([C:28]3[CH:29]=[C:30]([NH:34][C:35]([CH:37]4[CH2:39][CH2:38]4)=[O:36])[CH:31]=[CH:32][CH:33]=3)[CH2:24][CH2:23]2)=[O:11])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 64798Diphenylpropionic acidHCID 21957166N-{3-[1-(3-aminopropyl)4-piperidinyl]phenyl}cyclopropanecarboxamide

Product 1

HCID 10255746N-[3-(1-{3-[(3,3-diphenylpropanoyl)amino]propyl}-4-piperidinyl)phenyl]cyclopropanecarboxamide

Procedure

Example 151 was prepared from 3,3-diphenylpropanoic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}cyclopropanecarboxamide according to the procedures described in Scheme 9: ESMS m/e: 510.4 (M+H)+.

Sources & evidence

ORD record
ord-3bac6c4db3a84524af5d7e0fdf5abed7
Source dataset
uspto-grants-2006_09
Patent number
US07105544B2

Reaction notes

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