Ammonia → 2-Chloro-4-methyl-1,3-thiazole-5-sulfonamide

Participants

Reaction Steps

At −10° C., 117.7 g (1.8 mol) of a 26% strength aqueous ammonia solution are added dropwise to a solution of 208 g (95% strength, 0.9 mol) of 2-chloro-4-methyl-1,3-thiazole-5-sulphonyl chloride in 1000 ml of tetrahydrofuran. The mixture is stirred without further cooling for 2 h and the reaction mixture is then concentrated using a rotary evaporator. The crude product is used for the next step without further purification.

Provenance & Evidence