HCID 68686617, compound → HCID 21957871, compound

Participants

Reaction Steps

A solution of 2.98 g (12.9 mmol) 1-(3-methyl-1-trifluoromethyl-but-1-enyl)-2-nitrobenzene in 30 ml methanol is hydrogenated over Raney-Nickel (ethanol) at 100° C. and 150 bar for 10 hours. Then the catalyst is filtered off and the solvent removed in a water-jet vacuum. The obtained crude product is purified by column chromatography over silica gel (eluant: hexane/methylene chloride=1:2). Yield: 1.9 g 2-(3-methyl-1-trifluoromethyl-butyl)phenylamine in the form of a brown oil (1H-NMR).

Provenance & Evidence