4-Acetylpyridine → 4-(2,4-Dioxo-4-pyridin-4-ylbutyl)piperidine-1-carboxylic acid tert-butyl ester

HRID 221354Notes

Reaction equation

HRID 221354 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[C:10]([O:14][C:15]([N:17]1[CH2:22][CH2:21][CH:20]([CH2:23][C:24](O)=[O:25])[CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:12])[CH3:11]>>[C:10]([O:14][C:15]([N:17]1[CH2:22][CH2:21][CH:20]([CH2:23][C:24](=[O:25])[CH2:2][C:1](=[O:3])[C:4]2[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=2)[CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:12])[CH3:11]

Participants

3

Reactant 2

HCID 142824-AcetylpyridineHCID 1512539[1-(tert-Butoxycarbonyl)piperidin-4-yl]acetic acid

Product 1

HCID 579543874-(2,4-Dioxo-4-pyridin-4-ylbutyl)piperidine-1-carboxylic acid tert-butyl ester

Procedure

Condensation of 4-acetylpyridine with 4-carboxymethylpiperidine-1-carboxylic acid tert-butyl ester, utilising the protocol described in Preparation 22, afforded the title compound: m/z (ES+)=247.2 [M-Boc+H]+.

Workup

  1. customdescribed in Preparation 22

Sources & evidence

ORD record
ord-b95799cb3e1c409391bc060b5b56035b
Source dataset
uspto-grants-2012_06
Patent number
US08207147B2

Reaction notes

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