Potassium Hydroxide → HCID 21957570, compound

Participants

Reaction Steps

A solution of the product from step b (1.43 g, 3.65 mmol) and potassium hydroxide (632 mg, 11.3 mmol) in ethanol/water (14 mL/2 mL) was heated at reflux for 2 h. The reaction mixture was allowed to cool and diluted with water (30 mL). The reaction mixture was washed with ether (30 mL) and the organic phase was discarded. The pH of the aqueous phase was adjusted to 1 with aqueous 2M hydrochloric acid and extracted twice with chloroform (40 mL). The combined chloroform extracts were dried (MgSO4) and the filtrate evaporated at reduced pressure to afford the title compound (1.16 g, 87%). 1H NMR (CDCl3) 7.52 (3H, m), 7.33-7.27 (2H, m), 7.08-6.99 (3H, m), 5.54 (2H, s).

Provenance & Evidence