HCID 69651826, compound → HCID 21957565, compound

Participants

Reaction Steps

5-(Adamantan-1-yloxymethyl)-3-cycloheptyl-3H-[1,2,3]triazole-4-carboxylic acid methyl ester was converted to the corresponding acid (as in Example 28, step c) which was then coupled to methyl 3-aminobenzoate (as in Example 28, step d). Hydrolysis of the methyl ester (as in Example 28, step e) resulted in the preparation of 3-{[5-(adamantan-1-yloxymethyl)-3-cycloheptyl-3H-[1,2,3]triazole-4-carbonyl]-amino}-benzoic acid. 1H NMR (d6-DMSO) 13.02 (1H, s), 10.64 (1H, s), 8.29 (1H, s), 7.89 (1H, d, J=9 Hz), 7.73 (1H, d, J=6 Hz), 7.54-7.49 (1H, m), 4.96-4.92 (1H, m), 4.73 (2H, s), 2.10-2.02 (7H, m), 1.78-1.45 (20H, m). The material was further analysed as its N-methyl D-glucamine salt.

Provenance & Evidence