HCID 69651910, compound → HCID 21957557, compound

Participants

Reaction Steps

5-(Adamantan-1-yloxymethyl)-1-cycloheptyl-3H-[1,2,3]triazole-4-carboxylic acid methyl ester was converted to the corresponding acid (as in Example 28, step c) which was then coupled to methyl 3-aminobenzoate (as in Example 28, step d). Hydrolysis of the methyl ester (as in Example 28, step e) resulted in the preparation of 3-{[5-(adamantan-1-yloxymethyl)-1-cycloheptyl-3H-[1,2,3]triazole-4-carbonyl]-amino}-benzoic acid. 1H NMR (d6-DMSO) 12.91 (1H, s), 10.62 (1H, s), 8.51 (1H, m), 7.98-7.95 (1H, m), 7.68 (1H, d, J=9 Hz), 7.47-7.42 (1H, m), 4.98 (2H, s), 4.71-4.66 (1H, m), 2.48-2.07 (7H, m), 1.80-1.54 (20H, m). The material was further analysed as its N-methyl D-glucamine salt.

Provenance & Evidence