Toluene → HCID 21957938, compound

HRID 2213656Notes

Reaction equation

HRID 2213656 reaction equation
[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][NH:14][C:15]2[CH:20]=[CH:19][C:18](C(C)C)=[CH:17][CH:16]=2)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:24]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([CH:33]([CH3:35])[CH3:34])[C:28]=1[N:36]=[C:37]=[O:38])([CH3:26])[CH3:25].[C:39]1(C)[CH:44]=CC=C[CH:40]=1>>[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][N:14]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:20]=2[CH:39]([CH3:44])[CH3:40])[C:37]([NH:36][C:28]2[C:29]([CH:33]([CH3:34])[CH3:35])=[CH:30][CH:31]=[CH:32][C:27]=2[CH:24]([CH3:25])[CH3:26])=[O:38])[CH:10]=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 1140TolueneHCID 922592,6-Diisopropylphenyl isocyanateHCID 21957926HCID 21957926, compound

Product 1

HCID 21957938HCID 21957938, compound

Procedure

To a solution of [(1-benzylpyrazol-4-yl)methyl](4-isopropylphenyl)amine (0.17 g) in toluene (5 mL) was added 2,6-diisopropylphenyl isocyanate (0.12 mL) and the mixture was stirred overnight at room temperature. The reaction mixture was washed with saturated brine and dried over magnesium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography to give N-[(1-benzylpyrazol-4-yl)methyl]-N′-(2,6-diisopropylphenyl)-N-(isopropylphenyl)urea (0.24 g).

Workup

  1. washThe reaction mixture was washed with saturated brine
  2. dry with materialdried over magnesium sulfate
  3. customThe solvent was evaporated under reduced pressure
  4. customthe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-ef089b70f1ce4cba833edbf8a9a8f553
Source dataset
uspto-grants-2006_09
Patent number
US07105567B2

Reaction notes

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