Water → HCID 10488085, compound

Participants

Reaction Steps

A mixture of AlCl3 (24.02 g) and dichloromethane (400 mL) was treated with (carbomethoxy)propionyl chloride (27.05 g). A solution of pyrrole (10.01 g) in dichloromethane (150 mL) was then added dropwise. After stirring overnight, the reaction mixture was poured over ice and water (500 mL). The resulting mixture was then extracted with dichloromethane (500 mL). The combined organic layers were washed with brine (500 mL), dried (MgSO4) and concentrated to afford γ-oxo-1-H-pyrrole-3-butanoic acid ethyl ester (5.14 g).

Provenance & Evidence