HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Oxo-2,3-dihydro-1H-indole-5-carbonitrile → 5-(Aminomethyl)indolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Oxo-2,3-dihydro-1H-indole-5-carbonitrile | HCID 2773346 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 5-(Aminomethyl)indolin-2-one | HCID 17982555 | 107.2% |
Reaction Steps
A slurry of 5-cyanoindolin-2-one (5 g, 31.64 mmol) and 10% palladium on carbon (500 mg), was hydrogenated under 40 psi at ambient temperature temp. for 24 hours. Filtration through a pad of celite and concentration afforded 5-aminomethylindolin-2-one (5.5 g) as an orange oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07105563B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-cd3537787a68435a86cb5a7152035f46 |
| Source note | uspto-grants-2006_09 |