2,2,2-Trichloroethyl chloroformate → HCID 57954385, compound

Participants

Reaction Steps

The tert-butoxycarbonyl group of 4-{[methyl(3-pyridin-4-yl-[1,2,4]oxadiazol-5-ylmethyl)amino]methyl}piperidine-1-carboxylic acid tert-butyl ester (Example 124) was removed using the procedure described in Example 51 to afford methylpiperidin-4-ylmethyl-(3 pyridin yl-[1,2,4]oxadiazol-5-ylmethyl)amine: RT=0.75 min; m/z (ES+)=288.0 [M+H]+. Derivatisation of methylpiperidin-4-ylmethyl-(3-pyridin-4-yl-[1,2,4]oxadiazol-5-ylmethyl)amine with 2,2,2-trichloroethylchloroformate, using the procedure described for Example 52, afforded the title compound: RT=3.51 min; m/z (ES+)=461.9 [M+H]+.

Provenance & Evidence