Triethylamine → HCID 131725933, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1.5 mmol 1,1,1-trifluorobutane-4-amine, 1.5 mmol triethylamine in 10 ml dichloromethane is added to a solution of 1.5 mmol 5,7-dichloro-6-(2-chloro-6-fluorophenyl)-[l,2,4]-triazolo[1,5-α]pyrimidine [cf. EP-A 550 113] in 20 ml dichloromethane. The combined solution was stirred for about 16 hours at 20 to 25° C. and subsequently washed with diluted (5%) hydrochloric acid. The organic phase was separated, dried and filtered. Distillative removal of the solvent from the filtrate and chromatography over silica gel yielded 0.45 g of the title compound of mp. 115° C.

Provenance & Evidence