Diisopropylaniline → HCID 178486496, compound

Participants

Reaction Steps

2,6-Diisopropylaniline (9.62 ml, 51 mmol) and 2-chloro-9,10-dimethoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one (5 g, 17 mmol) were suspended in propan-2-ol (400 ml ) and heated at reflux, under nitrogen, for 4 days. After cooling to room temperature, the solution was concentrated in vacuo and the residue purified by flash column chromatography [dichloromethane/methanol (98:2–96:4)] to afford the title compound (5.8 g, 79%) as a yellow/orange solid.

Provenance & Evidence