HCID 21956470, compound → HCID 69372248, compound

HRID 2213745Notes

Reaction equation

HRID 2213745 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[NH:12][C:13](=O)[CH2:14][Cl:15])[N:8]=[CH:7][C:6]([C:17]#[N:18])=[C:5]2[NH:19][C:20]1[CH:25]=[C:24]([O:26][CH3:27])[C:23]([O:28][CH3:29])=[C:22]([O:30][CH3:31])[CH:21]=1>C(O)(=O)C>[Cl:15][CH2:14][C:13]1[N:12]=[C:11]2[CH2:10][C:9]3[N:8]=[CH:7][C:6]([C:17]#[N:18])=[C:5]([NH:19][C:20]4[CH:21]=[C:22]([O:30][CH3:31])[C:23]([O:28][CH3:29])=[C:24]([O:26][CH3:27])[CH:25]=4)[C:4]=3[CH:3]=[C:2]2[N:1]=1

Participants

3

Reactant 1

HCID 21956470HCID 21956470, compound

Product 1

HCID 69372248HCID 69372248, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A of 0.11 g (0.25 mmol) sample of product from Example 46 in 3.0 mL of glacial acetic acid is heated at 100° C. for 15 minutes, then cooled to room temperature. Following evaporation of the solvent in vacuo, the residue is suspended in water and neutralized with solid sodium carbonate. The solid is collected by filtration, washed with water and dried to yield 0.1 g of 2-(chloromethyl)-8-(3,4,5-trimethoxyanilino)imidazo[4,5-g]quinoline-7-carbonitrile as a yellow solid.

Workup

  1. customevaporation of the solvent in vacuo
  2. filtrationThe solid is collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-8325b0c03a5f4f33899f823c006d17f3
Source dataset
uspto-grants-2006_09
Patent number
US07105531B2

Reaction notes

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