2-Propenoic acid, 3-(4-aminophenyl)-, hydrochloride → HCID 86760247, compound

Participants

Reaction Steps

An analogous reaction to that described in example 3c, but starting with 4-chloro-6-methoxy-7-(2,2,2-trifluoroethoxy)quinazoline (4.50 g, 15.4 mmol) and 4-aminocinnamic acid hydrochloride (3.07 g, 15.4 mmol) yielded 4-(4-(2-carboxy)ethenyl)anilino)-6-methoxy-7-(2,2,2-trifluoroethoxy)quinazoline hydrochloride (5.17 g, 74% yield) as a white solid:

Provenance & Evidence