Lansoprazole sulfide → HCID 178495390, compound

HRID 2213876Notes

Reaction equation

[CH3:1][O:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([CH2:13][S:14][C:15]2[NH:19][C:18]3[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=3[N:16]=2)[C:8]=1[CH3:24].CC1C([O:43]CC(F)(F)F)=CC=NC=1CSC1NC2C=CC=CC=2N=1>>[CH3:24][C:8]1[C:9]([CH2:13][S+:14]([O-:43])[C:15]2[NH:19][C:18]3[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=3[N:16]=2)=[N:10][CH:11]=[CH:12][C:7]=1[O:6][CH2:5][CH2:4][CH2:3][O:2][CH3:1]

Participants

Reactant 2

HCID 1094080Lansoprazole sulfide

HCID 9949996Rabeprazole-thioether

Product 1

HCID 178495390HCID 178495390, compoundYield 75%

Procedure

The experiment described in example 2 was repeated using 48.8 g of 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-1H-benzimidazole as substrate instead of Lansoprazole sulfide. 38.3 g of crystallized Rabeprazole are isolated after crystallization and drying (yield 75%).

Sources & evidence

ORD record: ord-69d60197102e4d3f824d54a113e7696c
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07105681B2

Reaction notes

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