反应详情

3-Amino styrene (1.36 g, 11.4 mmol) was added to a solution of 2′,4′-difluorobiphenyl-4-sulphonyl chloride (3.0 g, 10.3 mmol) in DCM (25 mL) at 0° C. Pyridine (6.0 mL, 74 mmol) was then added and the mixture was allowed to stir and warm to room temperature overnight. The reaction was partitioned between further DCM (100 mL) and 2 M HCl (30 mL), stirred and separated. The DCM layer was washed with water (20 mL) and brine (20 mL) and dried over MgSO4. The solvent was evaporated and the title compound obtained as an orange gum (3.46 g) which was used without further purification.

1. customThe reaction was partitioned between further DCM (100 mL) and 2 M HCl (30 mL)
2. stirringstirred
3. customseparated
4. washThe DCM layer was washed with water (20 mL) and brine (20 mL)
5. dry with materialdried over MgSO4
6. customThe solvent was evaporated