4-(4-Nitrophenyl)-1-piperazinepropanol → 4-(3-Hydroxypropyl)-1-(4-isothiocyanatophenyl)piperazine

HRID 2213900Notes

Reaction equation

HRID 2213900 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][OH:19])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-])=O.[N-]=[C:21]=[S:22]>>[OH:19][CH2:18][CH2:17][CH2:16][N:13]1[CH2:14][CH2:15][N:10]([C:7]2[CH:8]=[CH:9][C:4]([N:1]=[C:21]=[S:22])=[CH:5][CH:6]=2)[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 219589334-(4-Nitrophenyl)-1-piperazinepropanolHCID 178418790HCID 178418790, compound

Product 1

HCID 99654394-(3-Hydroxypropyl)-1-(4-isothiocyanatophenyl)piperazine

Procedure

This compound was prepared from 4-(4-nitrophenyl)-1-piperazine-propanol (which can be prepared according to the procedure of Loewe and Mieth Arzneim.-Forsch. 1966; 16, 1306–1310) using the hydrogenation and isothiocyanate-forming reactions used in Example 4. MS (ES) MH+=277.

Workup

  1. customcan be prepared
  2. customforming reactions

Sources & evidence

ORD record
ord-0bfcd54ead6b4613b91180f4ed38a094
Source dataset
uspto-grants-2006_09
Patent number
US07105670B2

Reaction notes

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