反应详情

Dry meta-chloroperoxybenzoic acid (˜85%, dried over KOH in a clean, dry, uncontaminated vacuum desiccator for at least 48 hours; 3.7 g, 21 mmol) was added to a solution of 2′,4′-difluoro-N-(3-vinylphenyl)biphenyl-4-sulfonamide (1.16 g, 4.3 mmol) in dry DCM (30 mL) at 0° C. The mixture was allowed to warm to room temperature and stirred for 5 hours. Water (30 mL) was added and the layers were separated. The DCM layer was washed with 10% Na2SO3 (30 mL), saturated NaHCO3 (30 mL), water (30 mL) and brine (30 mL) and dried over MgSO4. The solvent was evaporated and the title compound obtained as an orange oil (1.16 g) which was used without further purification.

1. dry with materialDry meta-chloroperoxybenzoic acid (˜85%, dried over KOH in a clean,
2. customdry
3. waituncontaminated vacuum desiccator for at least 48 hours
4. customthe layers were separated
5. washThe DCM layer was washed with 10% Na2SO3 (30 mL), saturated NaHCO3 (30 mL), water (30 mL) and brine (30 mL)
6. dry with materialdried over MgSO4
7. customThe solvent was evaporated