Phosphoric Acid → HCID 86586146, compound

HRID 2213916Notes

Reaction equation

HRID 2213916 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH2:29][CH2:28][N:27]([CH:30]([CH3:32])[CH3:31])[CH2:26][CH2:25]3)=[CH:20][CH:19]=2)[S:5][C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)=[O:8].[P:33](=[O:37])([OH:36])([OH:35])[OH:34]>C(O)C>[P:33](=[O:34])([OH:37])([OH:36])[OH:35].[NH2:1][C:2]1[N:3]=[C:4]([NH:17][C:18]2[CH:19]=[CH:20][C:21]([N:24]3[CH2:25][CH2:26][N:27]([CH:30]([CH3:32])[CH3:31])[CH2:28][CH2:29]3)=[CH:22][CH:23]=2)[S:5][C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)=[O:8]

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 9933545HCID 9933545, compound

Product 1

HCID 86586146HCID 86586146, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of {4-amino-2-[4-(4-isopropyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-methoxy-phenyl)-methanone (of Example 43; 113 mg, 0.25 mmol) was dissolved in hot ethanol (10 ml) and to this was added 25 mg of phosphoric acid in ethanol (1 ml). This was cooled and crystals were collected and dried to furnish {4-Amino-2-[4-(4-isopropyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-methoxy-phenyl)-methanone; compound with phosphoric acid. MicroAnalysis C, H, N, P, and S.

Workup

  1. temperatureThis was cooled
  2. customcrystals were collected
  3. customdried

Sources & evidence

ORD record
ord-8086a775aaf943c68e548504c2c32f23
Source dataset
uspto-grants-2006_09
Patent number
US07105670B2

Reaction notes

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