HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanamide → {4-Amino-2-[4-(4-cyclopropylmethyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-methoxy-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanamide | HCID 9864 | — |
| Reactant | Bromomethyl 3-methoxyphenyl ketone | HCID 101294 | — |
| Reactant | 1-(4-Isothiocyanatophenyl)-4-cyclopropylmethylpiperazine | HCID 21958916 | — |
| Product | {4-Amino-2-[4-(4-cyclopropylmethyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-methoxy-phenyl)-methanone | HCID 21958932 | — |
Reaction Steps
This compound was prepared from cyanamide, 1-(4-isothiocyanato-phenyl)-4-cyclopropylmethylpiperazine (of Example 14G), and 2-bromo-1-(3-methoxyphenyl)ethanone (Aldrich) following-the procedure used in Example 24 Mass spectrum (ES) MH+=464.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07105670B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-6e582a482970436d8091abc1960ec97f |
| Source note | uspto-grants-2006_09 |