Cyanamide → {4-Amino-2-[4-(4-cyclopropylmethyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-fluoro-4-hydroxy-phenyl)-methanone

Participants

Role	Name	HCID	Charge
Reactant	Cyanamide	HCID 9864	—
Reactant	2-Bromo-1-(3-fluoro-4-hydroxyphenyl)ethan-1-one	HCID 17923530	—
Reactant	1-(4-Isothiocyanatophenyl)-4-cyclopropylmethylpiperazine	HCID 21958916	—
Product	{4-Amino-2-[4-(4-cyclopropylmethyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-fluoro-4-hydroxy-phenyl)-methanone	HCID 21958944	—

Reaction Steps

This compound was prepared from cyanamide, 1-(4-isothiocyanato-phenyl)-4-cyclopropylmethylpiperazine (of Example 14G) and 2-bromo-1-(3-fluoro-4-hydroxyphenyl)ethanone (of Example 14M) following the procedure used in Example 24. Mass spectrum (ES) MH+=468.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07105670B2
Source dataset	uspto-grants-2006_09
ORD ID	ord-e64ca122d61f487bb7252c5aba894242
Source note	uspto-grants-2006_09